We are part of Sackler Faculty of Medicine and Sagol School of Neuroscience at Tel Aviv University.

 

Our research utilizes state-of-the-art technologies to elucidate cellular mechanisms of neurological disorders. Some of these diseases progress late in life, such as Huntington's disease and Parkinson's disease.

A common characteristic of these diseases is the accumulation of proteins that are not folded properly and can form aggregates in cells. 

 We aim to elucidate novel regulatory pathways of protein homeostasis in cells to better understand the basis of these devastating diseases and to identify future therapeutic targets. 

  • Avraham Ashkenazi Lab

Recent lab news

Congratulations! Rita for MSc scholarship and Fatima for the travel grant from APPD

Our review on ubiquitin signaling and aggregate-prone proteins is out

Parkinson's disease spotlight

Molecular Cell  73, 5-6

Autophagy, ubiquitin and polyglutamine diseases 

Nature  545, 108–111 

Expanded polyglutamine (polyQ) tracts in different proteins are a common feature of many neurodegenerative diseases. Many normal proteins also carry these tracts, although their function remains unclear. We show that polyQ tracts in a normal ataxin protein have a role in the degradative process of autophagy. In this case, the polyQ domain allows ataxin 3 interaction with the autophagy mediator beclin 1. Ataxin 3 can thus deubiquitinate beclin 1, preventing its degradation by the proteasome and allowing it to initiate autophagy. We not only demonstrate the relevance of our findings to the process of autophagy in neurons, but also show how, under disease conditions, the polyQ tracts in mutant proteins compete with those in ataxin 3 to prevent beclin 1 stabilization and so impair starvation-induced autophagy.

Our research combines different technological approaches both in-vitro and in-vivo to understand key questions in cell biology that are related to protein misfolding disorders.

We are always seeking highly motivated individuals to join our lab. 

Contact Us

Dr. Avraham Ashkenazi 

Dept. Cell and Developmental Biology

Sackler Faculty of Medicine 

Tel Aviv University 

Tel Aviv 6997801  Israel

ashkenaziavi@tauex.tau.ac.il

  • Avraham Ashkenazi Lab

©2018 by Avraham Ashkenazi

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