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Avraham Ashkenazi Lab
for understanding the cell biology of protein misfolding and neurological disorders
Ishtayeh, H., Galves, M., Barnatan, T.T., Berdichevsky, Y., Amer-Sarsour, F., Pasmanik-Chor, M., Braverman, I., Blumen, S.C., Ashkenazi, A. (2023) Oculopharyngeal muscular dystrophy mutations link the RNA-binding protein HNRNPQ to autophagosome biogenesis. Aging Cell 10, e13949.
Sharabi, Y., Vatine, G. D., and Ashkenazi, A. (2022) Autonomic nervous system disorders. Neuron 8, 1432-1432.
Hill, S.M., Wrobel, L., Ashkenazi, A., Fernandez-Estevez, M., Tan, K., Bürli, R.W., and Rubinsztein, D.C. (2021) VCP/p97 regulates Beclin-1-dependent autophagy initiation. Nature Chemical Biology 17, 448-455.
Amer-Sarsour, F., Kordonsky, A., Berdichevsky, Y., Prag, G., and Ashkenazi, A. (2021) Deubiquitylating enzymes in neuronal health and disease. Cell Death & Disease 12(1),120.
Sharabi, Y., Vatine, G. D., and Ashkenazi, A. (2021) Parkinson's disease outside the brain: targeting the autonomic nervous system. Lancet Neurology 20, 868-876.
Falik, D., Rabinski, T., Zlotnik, D., Eshel. R., Zorsky, M., Garin-Shkolnik, T., Ofir, R., Adato, Ashkenazi, A., Vatine. G.D. (2020) Generation and characterization of iPSC lines from two identical twins with poly-alanine expansion in the paired-like homeobox 2B (PHOX2B) gene. Stem Cell Research 48, 101955.
Stok, R., and Ashkenazi, A. (2020) Lipids as the key to understanding α-synuclein behaviour in Parkinson disease. Nature Reviews Molecular Cell Biology 21, 357–358.
Amer-Sarsour, F., and Ashkenazi, A. (2019) The Nucleolus as a Proteostasis Regulator. Trends in Cell Biology 29, 849-851.
Galves, M., Rathi, R., Prag, G., and Ashkenazi, A. (2019) Ubiquitin signaling and degradation of
aggregate-prone proteins. Trends in Biochemical Sciences 44, 872-884.
Donyo, M., and Ashkenazi, A. (2019) The cell-death-associated polymer PAR feeds forward α-Synuclein toxicity in Parkinson's disease. Molecular Cell 73, 5-6.
Puri, C.*, Vicinanza, M.*, Ashkenazi, A., Gratian, M. J., Zhang, Q., Bento, C. F., Renna, M., Menzies, F. M. and Rubinsztein, D. C. (2018) The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A. Developmental Cell 45, 114-131
* Joint first authors
Ejlerskov, P.*, Ashkenazi, A.* and Rubinsztein, D. C. (2018) Genetic enhancement of macroautophagy in vertebrate models of neurodegenerative diseases. Neurobiology of Disease 18, 30110-30114
* Joint first authors
Ashkenazi, A., Bento, C. F., Ricketts, T., Vicinanza, M., Siddiqi, F., Pavel, M., Squitieri,F., Hardenberg, M. C., Imarisio, S., Menzies, F. M., and Rubinsztein, D. C. (2017) Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature 545, 108–111
Menzies, F. M*., Fleming, A.*, Caricasole, A.*, Bento, C. F.*, Andrews, S. P.*,
Ashkenazi, A.*, Fullgrabe, J.*, Jackson, A.*, Jimenez Sanchez, M.*, Karabiyik, C.*, Licitra, F.*, Lopez Ramirez, A.*, Pavel, M.*, Puri, C.*, Renna, M.*, Ricketts, T.*, Schlotawa, L. *, Vicinanza, M.*, Won, H.*, Zhu, Y.*, Skidmore, J.*, and Rubinsztein, D. C. (2017) Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic
Opportunities. Neuron 93, 1015-1034
* Joint first authors
Bento, C. F., Ashkenazi, A., Jimenez-Sanchez, M., and Rubinsztein, D. C. (2016) The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nature Communications 7, 11803
Bento, C. F*., Renna, M.*, Ghislat, G.*, Puri, C.*, Ashkenazi, A.*, Vicinanza, M.*, Menzies, F. M.*, and Rubinsztein, D. C. (2016) Mammalian Autophagy: How Does It Work? Annual Review of Biochemistry 85, 685-713
* Joint first authors
Vicinanza, M., Korolchuk, V. I., Ashkenazi, A., Puri, C., Menzies, F. M., Clarke, J. H., and Rubinsztein, D. C. (2015) PI(5)P regulates autophagosome biogenesis. Molecular Cell 57, 219-234
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